Health Condition 1: T314- Burns involving 40-49% of body surface
Conditions
Interventions
Intervention1: Group P POCUS guided fluid resuscitation: In the POCUS group, fluid resuscitation will be initiated at an hourly rate calculated as per modified Brookeâ??s formula. The investigator wil
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1.Adult patients (18 â?? 65 years) 2.Severe burns involving 40 â?? 80% TBSA (excluding 1st degree burn area) 3.Admitted to ICU within 24 hours of injury
Exclusion criteria
Exclusion criteria: 1.Refusal of consent 2.Extremes of body mass index (BMI less than 17 or more than 35) 3.Extremes of body stature (height less than 150 cm or more than 190 cm) 4.Patients who have received more than 6 hours of formal fluid resuscitation prior to ICU admission 5.Hemodynamically unstable patients on moderate to high dose vasopressor support (noradrenaline requirement more than 0.1 mcg/kg/min or equivalent) 6.Pregnancy 7.Extensive deep burns involving anterior torso limiting scope for repeated POCUS assessment due to difficulty in obtaining an ultrasound window 8.Known cardiac disease 9.Chronic kidney disease on haemodialysis 10.Chronic decompensated liver disease (Child-Pugh C) 11.Severe ARDS at presentation 12.Patients not expected to survive beyond 24 hours 13.Patients with associated major trauma 14.Do not resuscitate orders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in total resuscitation volume over initial 24 hours.Timepoint: Difference in total resuscitation volume over initial 24 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Difference in cumulative fluid balance, lactate levels, base excess, SOFA scores, LUS scores, PaO2:FiO2 ratio and serum creatinine. 2.Difference in SOFA score 3.Difference in incidence of ARDS,AKI,need for respiratory support,need for renal support mortality, organ failure free days and ICU free days. Timepoint: 24h 48h 72h 72h 7days 30 days | — |
Countries
India
Contacts
Public ContactPriyankar Kumar Datta
All India Institute of Medical Sciences
Outcome results
None listed