Health Condition 1: - Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Inj.Labetalol hydrochloride
: Injection labetalol 0.25mg/kg in 10 ml NS over 5 minutes and will be stoped 5 minutes before induction
Intervention2: Inj.dexmedetomidine hydrochloride:
Sponsors
Health and family welfare department
Eligibility
Inclusion criteria
Inclusion criteria: Patients of age between 18-60 years of both gender ASA 1 and 2 Undergoing elective surgical procedure requiring general anaesthesia and endotracheal intubation Written and informed consent.
Exclusion criteria
Exclusion criteria: Patient refusal to participate in the study Allergy to study medications Patients with H/o cardiac, respiratory, renal or hepatic dysfunction or failure. Pregnant females Patients on Antihypertensive drugs Patients with difficult intubation and those patients in whom intubation was attempted for more than 30 seconds or 2 attempts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of attenuation of Haemodynamic stress response to Laryngoscopy and intubation after giving Inj.Labetalol and dexmedetomidineTimepoint: Assessment of attenuation of Haemodynamic stress response to Laryngoscopy and intubation after giving Inj.Labetalol and dexmedetomidine by comparing Haemodynamic parameters (HR,SBP,DBP,SPO2)at baseline,after infusion of study drug,after induction of anaesthesia,immediately after intubation,1,3,5,10 minutes after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative sedation by Ramsay scale and adverse effects if occursTimepoint: Sedation by Ramsay scale at immediately after intubation and 15min,30 min,1hr,2hr,4hr,6hr | — |
Countries
India
Contacts
Public ContactDrSeema Gandhi
B.J.Medical Collage,Ahmedabad
Outcome results
None listed