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A Clinical trial to study effect of combination of Topical Metronidazole and Diltiazem and compare it with effect of topical Diltiazem in treatment of Acute Anal Fissure

A Comparative Study between combination of Topical Metronidazole and Diltiazem vs Diltiazem alone in treatment of Acute Anal Fissure

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/01/048866
Enrollment
174
Registered
2023-01-10
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K600- Acute anal fissure

Interventions

Intervention1: metronidazol, diltiazem: topical metronidazole 1% ointment is prescribed along with topical diltiazem 2% ointment thrice a day applied on anal fissure for period of 4 week Control Inter

Sponsors

Dr Abhishek jain
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Acute anal fissure with complaints Age group > 18 year

Exclusion criteria

Exclusion criteria: Patient with chronic anal fissure. Patient with multiple fissures. Patients already on topical treatment. Patient with internal haemorrhoid except grade 1. Patients with perianal fistula & abscess. Patients with inflammatory bowel disease. Patients with immune deficiency; receiving oral immunosuppressive drugs or steroids. Patients with anal stenosis. Patients on oral anti-coagulants, or having ischemic heart disease. Pregnant females. Patient who donot give consent for the study.

Design outcomes

Primary

MeasureTime frame
1.Pain: by VAS score at 1st , 2nd and 4th week 2.Level of healing of fissure: Degree of epithelization will be determined as follows: 0 - no epithelialization in the fissure 1 - there is epithelialization in the fissure 2 - the fissure is fully healed. Timepoint: 4 week

Secondary

MeasureTime frame
Requirement of surgery for anal fissure: anytime before 4 weeks follow-up period Timepoint: 4 week

Countries

India

Contacts

Public ContactDr Abhishek jain

Peoples college of medical science

drnitin75@gmail.com9303235020

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026