Efficacy of kojic acid in reducation of melanin oral pigmentations

Evaluation of efficacy of kojic acid application in reduction of melanin pigmentation in oral cavity : A Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2023/01/048853

Enrollment

Registered

2023-01-10

Start date

Unknown

Completion date

Unknown

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K137- Other and unspecified lesions of oral mucosa

Interventions

Intervention1: Kojic acid: 2% Kojic acid and Vitamin C cream - Once a day during night times for 2 months Control Intervention1: Vaseline: once a day during night for 2 months

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with melanin oral pigmentation on oral cavity 2. Patient with Melanin oral pigmentation on oral cavity after cessation of smoking 3. Patients willing to participate in the study

Exclusion criteria

Exclusion criteria: 1. Patient with Adverse Habits like tobacco chewing, pan chewing, betel nut chewing 2. HIV Patients 3. Patient under Immunosuppressant drugs 4. Melanoma 5. Oral Cancer Patients 6. Patient with Reverse Smoking 7. Psychiatric Disorders 8. Migraine and Vascular Headache 9. Hypersensitivity to kojic acid

Design outcomes

Secondary

Measure	Time frame
reduction in melanin pigmentation on oral cavityTimepoint: 2 months	—

Primary

Measure	Time frame
reduction in melanin pigmentation on oral cavityTimepoint: 4 months	—

Countries

India

Contacts

Public ContactDr Chaitanya tvk

narayana dental college

dentkan1@gmail.com9490471078

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026