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Efficacy of melatonin with ibuprofen chronotherapy after periodontal surgery

A randomized controlled, double blind cross over trial to compare the efficacy of melatonin with ibuprofen chronotherapy to ibuprofen chronotherapy alone in reducing the pain perception after periodontal surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/01/048820
Enrollment
75
Registered
2023-01-09
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Melatonin plus ibuprofen chronotherapy: After periodontal surgery patients will be given ibuprofen 400mg twice daily at 8am and 2 pm for 3 days And melatonin 10 MG at 8pm for 3 days. P

Sponsors

Supriya Mishra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patient having generalized periodontitis needing periodontal flap surgery. Patients willing to undergo flap surgery Patients willing to participate in the study.

Exclusion criteria

Exclusion criteria: Patients with known systemic disorders and under medication for the same. Patients allergic to melatonin and/or ibuprofen Patients with a history of anti-inflammatory and/or antibiotic therapy over the last six months Patients with a history of periodontal therapy over the last six months Pregnant and lactating mothers

Design outcomes

Primary

MeasureTime frame
Pain perception will be lesser in the intervention group (melatonin with ibuprofen chronotherapy) than in the comparator groupsTimepoint: Pain perception will be checked 24 hours, 48 hours and 72 hours after surgery.

Secondary

MeasureTime frame
Adverse consequences after intervention therapy( melatonin with ibuprofen chronotherapy) will be lesser when compared to the comparator groups.Timepoint: 24 hours, 48 hours and 72 hours post surgery

Countries

India

Contacts

Public ContactSupriya Mishra

Government dental College and hospital raipur

dr.supriya4@gmail.com08223859339

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026