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Comparing effect of two drugs given locally to a patient taken up for general anaesthesia when securing an airway device.

Comparison of Lignocaine Nebulization versus Lignocaine Lozenges on hemodynamics during BlockBusterTM Airway Insertion in patients scheduled for General Anaesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/01/048818
Enrollment
100
Registered
2023-01-09
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Lignocaine Lozenges: Troikaa Xynova 200 Lozenges containing 200mg of Lignocaine for oral use till fully dissolved 5 minutes before taking patient to Operation Room Intervention2: Lignoc

Sponsors

Government Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients in age group of 18-60 years 2. American Society of Anaesthesiologists (ASA) Status I and II 3. Patients undergoing surgery requiring general anaesthesia with laryngeal mask airway not requiring any other laryngeal or pharyngeal intervention.

Exclusion criteria

Exclusion criteria: 1. Patients allergic to lignocaine hydrochloride 2. Patients with difficult airway with Airway difficulty score >8 3. Morbid obesity BMI > 35 kg/m2 4. Known airway pathology 5. Oropharyngeal surgeries 6. Surgery duration more than 3 hours 7. Patients at increased risk of aspiration like GERD, peptic ulcer, non fasting status 8. Previous upper gastrointestinal surgery 9. Known or anticipated difficult tracheal intubation or facemask ventilation 10. Coagulopathy or history of anticoagulant use 11. Cardiorespiratory or cerebrovascular disease 12. Cervical spine injury 13. Pregnant Patients

Design outcomes

Primary

MeasureTime frame
To study the Heart Rate, Noninvasive Blood Pressure, ECG changes and Oxygen Saturation in patients during BlockbusterTM LMA insertionTimepoint: All these parameters to be taken prior to intervention (baseline), immediately after intervention, at the time of airway insertion and 1 minute, 2 minutes, 3 minutes, 5 minutes and 10 minutes after airway insertion.—

Secondary

MeasureTime frame
ECG ChangesTimepoint: ECG Changes- Before intervention, after intervention, at the time of securing airway, 1min, 2 min, 3 min, 5 min, 10 min after securing airway;Anaphylaxis, Systemic toxicity, circulatory disturbances, neurological impairmentsTimepoint: Before intervention, after intervention, at the time of securing airway, 1min, 2 min, 3 min, 5 min, 10 min after securing airway Anaphylaxis - Immediately after intervention to note down any side effects related to the drug—

Countries

India

Contacts

Public ContactDr Vivek Pandit

Government Medial College and Hospital, Chandiagarh

manpreetdawar@gmail.com9646121503

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026