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"Evaluation of levels of biomarkers at different stages of orthodontic treatment"

Evaluation and comparison of levels of matrix metalloproteinase-8, osteocalcin and alkaline phosphatase in gingival crevicular fluid at different stages of orthodontic treatment: An in-vivo study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2023/01/048742
Enrollment
36
Registered
2023-01-04
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Micro-osteoperforation (MOPs): Micro-osteoperforation (MOPs)accelerating the rate of Orthodontic tooth Movement Control Intervention1: levels of biomarker: Split Mouth Design with respe

Sponsors

Rony T Kondody
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The inclusion criteria will include, patients requiring first premolar extraction cases, cases which belong to Anglesâ?? Class I bimaxillary, Class II Div 1 malocclusion (ANB 5degree), mandibular incisor irregularity of 4â??6 mm, good oral conditions with no bleeding on probing and also with no radiographic evidence of periodontal bone loss after the radiographic periapical examination

Exclusion criteria

Exclusion criteria: Patients who are taking various anti-inflammatory drugs, also patients with various local and general systemic conditions which could influence the levels of biomarkers

Design outcomes

Primary

MeasureTime frame
1.levels of Matrix Metalloproteinase-8, Osteocalcin, and alkaline phosphatase in GCF during the initial leveling and alignment stage by using two different archwires. 2. levels of Matrix Metalloproteinase-8, Osteocalcin, and alkaline phosphatase in GCF during initial space closure with and without micro-osteoperforation using the split-mouth design. 3. To compare rate of retraction between the conventional and micro osteoperforation groups in the digital model using the split-mouth design. 4. Compare the levels of Matrix Metalloproteinase-8, Osteocalcin, and alkaline phosphatase in GCF at debonding stage and after 6 months of the retention period.Timepoint: 4 years—

Secondary

MeasureTime frame
Evaluate levels of matrix metalloproteinase-8, osteocalcin, and alkaline phosphatase in gingival crevicular fluid at different stages of orthodontic treatmentTimepoint: 4 years—

Countries

India

Contacts

Public ContactDr Rony T Kondody

Sri Rajiv Gandhi College of Dental Sciences

ronykondody55@gmail.com7760250619

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026