Health Condition 1: J219- Acute bronchiolitis, unspecified
Conditions
Interventions
Intervention1: 7% hypertonic saline: 7% hypertonic saline(4ml) + 1:1000 epinephrine (0.5ml/kg) every 6 hourly for 72 hours or until discharge (whichever is earlier)
Control Intervention1: Control grou
Sponsors
NONE
Eligibility
Inclusion criteria
Inclusion criteria: 1.Children aged 1-24 months of age 2. Diagnosed with bronchiolitis- defined as viral prodrome for 2-3 days followed by LRTI as tachypnea, bilateral wheeze/ crepitations with or without crepitations 3. Bronchiolitis severity score more than or equal to 4
Exclusion criteria
Exclusion criteria: 1. A previous history of wheezing/ diagnosis of asthma 2.Any use of bronchodilators within 2 hours of presentation 3.History of congenital heart disease/ chronic pulmonary disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of hospital stay: from the time of enrollment to ready to discharge (i.e when child is clinically active, alert, accepting feed, Spo2 more than92% on room air, absence of general danger signs and parents ready to care at homeTimepoint: BSS at baseline, every 6 hrs, 72 hrs or discharge time | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in BSS score at 24, 48 and 72 hours or at discharge( whichever is earlier) 2. Need for respiratory support (HFNC/NIV/CPAP/MECHANICAL VENTILATION) 3.Complication rate following therapy 4 Safety profile and adverse effectsTimepoint: BSS score at 24, 48 and 72 hours | — |
Countries
India
Contacts
Public ContactDR PRAWIN KUMAR
ALL INDIA INSTITUTE OF MEDICAL SCIENCES, JODHPUR
Outcome results
None listed