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A prospective observational study of relation between the lupus nephritis patients peripheral blood lymphocyte subset( T and B lymphocytes , renal tissue inflammatory cell distribution (biopsy tissue ) and immunosppressive regimen of the same patient .

Clinical outcome correlation among newly diagnosed lupus nephritis patients in relation to peripheral blood lymphocyte subset, renal tissue inflammatory cell distribution and immunosuppressive regimen: A prospective observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/12/048594
Enrollment
100
Registered
2022-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N004- Acute nephritic syndrome with diffuse endocapillary proliferative glomerulonephritis

Interventions

Control Intervention1: NIL: NIL

Sponsors

kasturba medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: : All newly diagnosed renal biopsy proven Class 3, class 4, Class 5 or a combination class of lupus nephritis patients.

Exclusion criteria

Exclusion criteria: Patients with: A) Active / recent infection in the last two weeks B) Active Malignancy or blood dyscrasias C) Prior use of immunosuppression before renal biopsy , D) Failure to consent for study

Design outcomes

Primary

MeasureTime frame
1. To identify correlation if any, between lymphocyte subset distribution in the peripheral blood and in renal tissue. 2. To determine correlation if any, between peripheral blood lymphocyte subset and clinical remission achieved following immunosuppressive regimens at the end of six months of initial intensive treatment phase. Timepoint: 6 months—

Secondary

MeasureTime frame
1. To detect correlation if any, between peripheral blood lymphocyte subset, serum inflammatory markers and disease activity score at presentation. 2. To recognize any correlation between peripheral blood lymphocyte subset and incidence of serious infection during immunosuppressive therapyTimepoint: Till the end of the treatment—

Countries

India

Contacts

Public ContactKarthik Balasubramaniam

Kasturba medicall college, manipal

doctor.dharshan@gmail.com9901970787

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026