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A study to find which of two pain medicines will reduce the dose of anaesthesia drugs during operation for head and neck cancer

Comparison of Anaesthetic Sparing Effect And Perioperative Analgesic Requirements Between Intravenous Infusions Of Lignocaine And Dexmedetomidine In Head And Neck Oncosurgeries.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048585
Enrollment
60
Registered
2022-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous dexmedetomidine: A bolus of 1 microgram/kg of dexmedetomidine is given intravenously followed by an infusion of 0.5 mic/kg/hr upto half an hour before the end of operation C

Sponsors

Nizams Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All the patients undergoing elective composite resection and reconstruction surgery for head and neck cancers (cancer of tongue, palate, buccal mucosa, mandible, maxilla, pharynx and larynx) aged 18-60 years with BMI 25-35 kg/m2, ASA status of 1 AND 2, normal liver and renal function tests and agreed to participate in the research.

Exclusion criteria

Exclusion criteria: The study excludes those patients who have failed to comprehend visual analogue scale , have history of local anaesthetic allergy, cardiovascular , respiratory,neurological or metabolic diseases,history of chronic analgesic use, serum creatinine more than 2mg/dl, patients on dialysis or in sepsis, patients with current opioid intake and pregnancy. POSTINCLUSION EXCLUSION CRITERIA: Patients who had Intraoperative complications (massive bleeding > 30% total blood volume) and those requiring postoperative mechanical ventilation.

Design outcomes

Secondary

MeasureTime frame
SECONDARY OBJECTIVES: â?¢ The requirement of intraoperative inhalational anaesthetic (amount of isoflurane used). â?¢ Postoperative analgesic requirement. â?¢ Adverse effects, if any. Timepoint: From the start of surgery upto 24 hours postoperatively—

Primary

MeasureTime frame
AIM: To compare anaesthetic sparing effect and perioperative analgesic requirements between intraoperative infusions of lignocaine and dexmedetomidine in patients undergoing head and neck oncosurgeries.PRIMARY OBJECTIVE: To compare the requirement of intraoperative fentanyl between lignocaine and dexmedetomidine used for patients undergoing head and neck oncosurgeries.Timepoint: From the start of surgery upto 24 hours postoperatively—

Countries

India

Contacts

Public ContactDr Manjeera D

Nizams institute of Medical Sciences

indiradevraj@yahoo.co.in7729932044

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026