Health Condition 1: J189- Pneumonia, unspecified organism
Conditions
Interventions
Intervention1: INJECTION METHYLPREDNISOLONE 0.5 MG/KG EVERY 12 HOURS FOR 5 DAYS: Patients belonging to the intervention group, after giving proper consent and fulfilling the inclusion criteria will be
Sponsors
GOVERNMENT MEDICAL COLLEGE AND HOSPITAL
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age more than 18year. 2. Patients have clinical symptoms suggesting community acquired pneumonia (cough, fever, pleuritic chest pain and/or shortness of breath) 3. Patient who will be diagnosed as a case of severe community acquired pneumonia as per the criteria ATS IDSA 2007 4. Those who will give consent for study.
Exclusion criteria
Exclusion criteria: 1. Immunocompromised patients i.e. HIV infection, neutropenic patients(1000Ã?109 /L), stem cell transplant recipients, patients on immunosuppressive treatment other than corticosteroid, patients of leukemia/lymphoma, chronic liver disease, chronic kidney disease, coronary artery disease and/ or chronic heart failure. 2. Clinical suspicion of Tuberculosis 3. Gastrointestinal bleeding in past three months 4. Conditions requiring adjunctive long-term corticosteroid therapy (with an equivalent dose of Inj methylprednisolone 1mg/kg/d or more) 5. Patients with pneumonia secondary to aspiration, hospital-acquired infection, prior treatment in ICU or receipt of mechanical ventilation. 6. Evidence of empyema, cavitary lung lesion or lung abscess as a complication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in the rates of treatment failure (early, late and/or both)Timepoint: day 0, 3, 6 | — |
Secondary
| Measure | Time frame |
|---|---|
| Attainment of clinical stabilityTimepoint: day 0, 3, 6;Effect of corticosteroid therapy on length of stay in hospital.Timepoint: day 0, 3, 6;Mortality during index hospitalization and at 28 days post discharge.Timepoint: day 0, 3, 6, 28 | — |
Countries
India
Contacts
Public ContactDR ANURAG DAHRA
Government Medical College and Hospital Sector 32, Chandigarh
Outcome results
None listed