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Effect of Muscle paralyzing drug(CISATRACURIUM)on anti-fits/seizure drug (LEVETIRACETAM)in patients undergoing neurosurgery.

Effect of Cisatracurium induced neuromuscular blockade in Levetiracetam treated neurosurgical patients.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048574
Enrollment
88
Registered
2022-12-28
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G403- Generalized idiopathic epilepsy and epileptic syndromes

Interventions

Intervention1: Levetiracetam, Cisatracurium: 1) To determine the duration of action (in minutes)that is From administration of intubating dose to TOF more than or equal to 2 in minutes. 2) To deter

Sponsors

M S Ramaiah Medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American society of Anaesthesiology physical status 1-3 patients Patients receiving levetiracetam therapy for >1 month and are seizure free. Posted for elective neurosurgical patients.

Exclusion criteria

Exclusion criteria: 1.Refusal to consent for proposed study. 2.Patients on multiple anticonvulsant medication along with Levetiraetam. 3.GCS 4.Anticiated difficult airway. 5.Obese patients,BMI >30 6.Pregnancy. 7.Known case of neuromuscular disorder.

Design outcomes

Primary

MeasureTime frame
To compare the dose-response characteristics of Cisatracurium induced neuromuscular blockade in Levetiracetam treated neurosurgical patients and the control group (not on any anticonvulsant medication) 1) To determine the duration of action (in minutes) 2) To determine the interval between supplementary doses of Cisatracurium required (in minutes) 3) To estimate the total average dosage (mg) 4) To determine the Recovery time (minutes) Timepoint: 1)From administration of intubating dose to TOF more than or equal to 2 in minutes. 2)From TOF more than 2 to next TOF more than 2 in minutes. 3)From the beginning of anaesthesia to reversal from anaesthesia in minutes. 4)From last supplementary dose of cisatracurium to TOF more than 90% in minutes.—

Secondary

MeasureTime frame
1) To compare the Intraoperative hemodynamic variables between the two groups. 2) To compare the analgesic (fentanyl) requirement between the two groupsTimepoint: 1)Intraoperative hemodynamic changes like heart rate,SBP,DBP,MAP at baseline,post induction,post intubation,post intubation every 5 minutes for the first half an hour,every 15 minutes till the end of procedure,at extubation and 5 minutes post extubation. 2)Total analgesic(fentanyl)requirement from the beginning of anaesthesia till end of anaesthesia.—

Countries

India

Contacts

Public ContactDr Geetha L

M S Ramaiah Medical College.

geetha4kiran@yahoo.in9611897899

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026