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Administration of fluids for the prevention of fall in blood pressure due to drugs during surgery in elderly patients.

Vena cava ultrasound-guided crystalloid preloading for the prevention of post-induction hypotension in elderly patients undergoing general anaesthesia: A randomised control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048544
Enrollment
110
Registered
2022-12-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: ultrasound guided fluid therapy: ultrasound-guided fluid therapy given preoperatively. Quantity of 500ml, 250ml and 250 ml of Ringers lactate at 10-minute intervals. Control Interventi

Sponsors

AIIMS patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA 1, 2 and 3 2. Patients requiring general anaesthesia (induction with propofol) followed by endotracheal intubation for elective surgeries.

Exclusion criteria

Exclusion criteria: 1. patients with unstable angina, tight valvular lesions, and ejection fraction 2. Patients suffering from uncontrolled hypertension 3. Patients with uncompensated respiratory disease such as generalised wheezes, defective functional capacity, peripheral O2 saturation 4. Patients with high intraabdominal pressure compressing IVC) 5. Patients with anticipated difficult airway 6. Patients taking medications like ACE inhibitors 7. Patients with major peripheral vascular disease, severe vascular disease, autonomic nervous system disorders 8. patients with implanted pacemaker/cardioverter insitu or with mental incompetence.

Design outcomes

Primary

MeasureTime frame
? To evaluate and compare the incidence of post-induction hypotensive episodes with and without crystalloid preloading using inferior vena cava collapsibility index in elderly patientsTimepoint: 2 minutes, 4 minutes, 6 minutes, 8 minutes, 10 minutes after intubation

Secondary

MeasureTime frame
Changes in mean arterial pressure and heart rate at various time intervalsTimepoint: - 2 minutes, 4 minutes, 6 minutes, 8 minutes, 10 minutes after intubation;Maximum fall in MAP from baseline in %Timepoint: 2 minutes, 4 minutes, 6 minutes, 8 minutes, 10 minutes after intubation;Need for vasopressors during hypotensive episodesTimepoint: 2 minutes, 4 minutes, 6 minutes, 8 minutes, 10 minutes after intubation;Amount of post-induction fluid requirementTimepoint: 10 minutes

Countries

India

Contacts

Public ContactDr Swapnil Tiwari

All India Institute of Medical Science Patna

drabhyu@gmail.com9013512403

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026