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Comparison of the ability of the brain to adapt to change and its relation to genetic differences in patients with schizophrenia and depression as seen in brain stimulation tests and brain imaging tests.

Neuroimaging and genetic correlates of motor cortical neuroplasticity and implicit motor learning in patients with schizophrenia, major depressive disorder, and healthy controls: A transdiagnostic study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/12/048536
Enrollment
180
Registered
2022-12-27
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features Health Condition 2: F322- Major depressive disorder, singleepisode, severe without psychotic features Health Condition 3: F20- Schizophrenia

Interventions

None listed

Sponsors

Ashok Jammigumpula
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Schizophrenia Schizophrenia (according to DSM 5) with persisting symptoms Score of >=4 on one or more of the items of BPRS 4 (conceptual disorganization) 11 (suspiciousness) 12 (hallucinatory behaviour) 15 (unusual thought content) OR A score of >=12 on all the above items combined Right-handed in accordance with the Edinburgh Handedness Inventory Speak either Kannada or English Written informed consent Depression Major Depressive Disorder (according to DSM 5) with persisting symptoms HAMD-17 score >=18 Right-handed in accordance to the Edinburgh Handedness Inventory Speak either Kannada or English Written informed consent Healthy Controls Matched for age, gender and education Right-handed in accordance to the Edinburgh Handedness Inventory Speak either Kannada or English Written informed consent

Exclusion criteria

Exclusion criteria: Schizophrenia Any history of other major psychiatric disorders Neurological disorders associated with movement impairments SUD in the last six months (except nicotine) Pregnancy Any contraindication to HD-tDCS or TMS Depression Any history of other major psychiatric disorders Neurological disorders associated with movement impairments Bipolar depression Psychotic disorder or symptoms SUD in the last six months (except nicotine) Pregnancy Any contraindication to HD-tDCS or TMS Healthy Controls Any history of major psychiatric disorders SUD in the last six months (except nicotine) Neurological disorders associated with movement impairments Major psychiatric illnesses in first-degree relatives Pregnancy Any contraindication to HD-tDCS or TMS

Design outcomes

Primary

MeasureTime frame
RMT SI1mV SICI LICI ICF CSP Implicit motor learning (Serial Reaction Time Task) Neuroimaging (Structural and Functional MRI) Genetic polymorphism (BDNF and COMT) Timepoint: Onetime assessment—

Secondary

MeasureTime frame
NilTimepoint: Nil—

Countries

India

Contacts

Public ContactAshok Jammigumpula

Kasturba Medical College, Manipal

samir.kp@manipal.edu

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026