Health Condition 1: R652- Severe sepsis
Conditions
Interventions
Intervention1: ringers lactate bolus: To study the efficacy of Ringer�s lactate in fluid resuscitation as bolus fluid of 20ml/kg during the acute management of septic shock compared to Normal S
Sponsors
Christian Medical College and Hospital Ludhiana
Eligibility
Inclusion criteria
Inclusion criteria: Fulfilling criteria for sepsis and septic shock as per International Pediatric Sepsis Consensus Conference -2005 1.Suspected or proven infection caused by any pathogen or clinical syndrome with high probability of infection, associated with 2.Presence of at least two of the following clinical manifestations (requiring abnormal temperature or white blood cell count): 1.Temperature >38.5 ââ??¦C or 2.Tachycardia or bradycardia (values adjusted to age) 3.Tachypnea (according to the age range) unrelated to neuromuscular disease or anesthesia. 4.Elevated or suppressed leukocyte count according to values for each age group. 3.Septic shock: patient with sepsis with acute circulatory failure, persistent hypotension 1. Hypotension or 2. Reliance on vasoactive drug administration to maintain a normal blood pressure or 3. Two or more of the following signs of inadequate tissue perfusion -prolonged capillary refill, oliguria, metabolic acidosis, elevated blood lactate
Exclusion criteria
Exclusion criteria: 1.Consent refused by parents/guardian 2.Post cardiac arrest shock 3.Cardiogenic shock 4.Neurogenic shock 5.Burns, Road Traffic accident 6.Hypovolemic shock (dehydration, blood loss) 7.Pre-existing hepato-renal disease 8.Known inborn errors of metabolism 9.Death or DAMA within 24 hours of hospitalisation 10.Patients included in other studies on septic shock
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time taken and total volume of fluid required as per weight for reversal of shockTimepoint: every one hourly till shock reversal is achieved | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess safety profile of Ringers Lactate versus Normal saline ( allergic reaction, electrolyte imbalance, acid base disorder)Timepoint: Serum electrolyte every twelve hourly Arterial blood gas analysis with Lactate estimation every six hourly;2.Treatment outcomes of children with septic shock treated with RL versus NSTimepoint: EVERY 1 TO 6 HOURLY TILL DISCHARGE | — |
Countries
India
Contacts
Public ContactBeninsujalini B
Christian Medical College, Ludhiana
Outcome results
None listed