FindTrial
Sign In

Comparison of two different modes of cisatracurium(muscle relaxant) administration in spine surgeries like comparing the hemodynamic profile such as heart rate and mean arterial blood pressure and recovery from the effect of muscle relaxant with two different modes of administration

Comparison of hemodynamic changes and recovery characteristics in spine surgeries with continuous infusion versus intermittent boluses of cisatracurium

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048502
Enrollment
104
Registered
2022-12-26
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Cisatracurium as continuous infusion: Cisatracurium will be administered as continuous infusion with the dose of 2mcg/kg/min in spine surgeries with duration of 4 hours Control Interven

Sponsors

M S Ramaiah Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiology Physical Status 1 and 2 Spine Surgery under General Anaesthesia No known Neuromuscular diseases No known drug allergy

Exclusion criteria

Exclusion criteria: Patients failing to meet the inclusion criteria Patient refusal to sign the informed consent Chronic kidney disease Chronic liver disease Cardiac comorbidities like Ischemic heart disease, Congestive heart failure Bronchial asthma Significant water, electrolyte and acid-base balance disorders Bradycardia or arrhythmias on the day of surgery

Design outcomes

Primary

MeasureTime frame
Heart rate and mean arterial pressure will be assessed as primary outcome to compare between two modes of cisatracurium administrationTimepoint: Baseline,Induction,Intubation and at every 10 minutes intervals till the end of surgery—

Secondary

MeasureTime frame
To compare recovery characteristics such as time taken from stoppage of cisatracurium administration to reversal time(TOF ratio 70%) and time taken from reversal time to extubation(TOF ratio 90%) and total time from stoppage of cisatracurium administration to extubationTimepoint: Stoppage of cisatracurium administration, TOF ratio 70%, TOF ratio 90%—

Countries

India

Contacts

Public ContactDr Geetha C R

M S Ramaiah Medical College

jageedha@yahoo.com9900482828

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026