A study to compare the effect of opioid sparing anaesthesia with standard general anaesthesia practice for postoperative analgesia and quality of postoperative recovery after modified radical mastectomy

Effect of opioid sparing anaesthesia using costotransverse block v/s opioid based anaesthesia on post-operative analgesia in modified radical mastectomy: A Randomized Control Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/12/048491

Enrollment

Registered

2022-12-26

Start date

Unknown

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C509- Malignant neoplasm of breast of unspecified site

Interventions

Intervention1: Non opioid analgesia: Patient will be given preoperative costotransverse block along with preopertaive infusion of magnesium sulphate(30mg/kg) as slow iv infusion over 30 minutes, dexme

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to American Society of Anesthesiologists (ASA) physical status grade I and II aged between 25 to 65 years, scheduled to undergo MRM will be enrolled.

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Pre-existing infection at block site 3. Coagulation Disorder 4. Pregnant patients 5. Patient posted for repeat surgery. 6. Patient on beta blocker or any H/O CAD 7. Patients with Impaired KFT, LFT 8. Presence of any preoperative pain or history of chronic pain 9. History of psychiatric illness and pre-existing neurological deficits 10. Patient with morbid obesity BMI >40 kg/ m2

Design outcomes

Primary

Measure	Time frame
To compare the total amount of fentanyl consumption in both the groups for next 24 hours postoperatively.Timepoint: 24 hours	—

Secondary

Measure	Time frame
1. To compare time to use first rescue analgesia in both the groups. 2. To compare NRS pain scores in both groups at specified time intervals. 3. To compare the total dose of intraoperative fentanyl used as rescue. 4. To compare perioperative complications as hypotension, bradycardia, any other significant event. 5. To compare the quality of post-operative recovery using QoR 15 score.Timepoint: 24 hours	—

Measure

Time frame

1. To compare time to use first rescue analgesia in both the groups. 2. To compare NRS pain scores in both groups at specified time intervals. 3. To compare the total dose of intraoperative fentanyl used as rescue. 4. To compare perioperative complications as hypotension, bradycardia, any other significant event. 5. To compare the quality of post-operative recovery using QoR 15 score.Timepoint: 24 hours

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Countries

India

Contacts

Public ContactPriyanka Sethi

All India Institute of Medical Sciences, Jodhpur

dr.priyanka_sethi@yahoo.co.in9352206300

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026