Health Condition 1: N040- Nephrotic syndrome with minor glomerular abnormality
Conditions
Interventions
Intervention1: use of daily levamisole therapy in frequently relapsing nephrotic syndrome vs alternate day levamisole therapy: Daily levamisole therapy(2.5mg/kg/day) with alternate day prednisolone (1
Sponsors
Dr Poonam Dalal
Eligibility
Inclusion criteria
Inclusion criteria: children aged 2-14 yrs with frequently relapsing nephrotic syndrome will be enrolled
Exclusion criteria
Exclusion criteria: 1. Children with infrequent relapses. 2. Children with steroid resistant nephrotic syndrome defined by persistent proteinuria at 4 weeks after start of steroid treatment. 3. Children who have received any other steroid sparing agents like cyclophosphamide, mycophenolate mofetil and calcineurin inhibitors like cyclosporine or tacrolimus for frequent relapses 4.previous or current malignancy,DM type1,current liver disease or epileptic convulsions 5.hypersensitivity to levamisole or one of its substances(lactose) 6.congenital nephrotic syndrome or secondary nephrotic syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| success of levamisole therapy which will be defined as less than 2 relapses over a 6 month period while on alternate day or daily levamisoleTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| duration to first relapse and cumulative steroid dosage received within six months of start of interventionTimepoint: 6 months | — |
Countries
India
Contacts
Public ContactRashmi KR
Pt.B.D.Sharma PGIMS Rohtak
Outcome results
None listed