A research study to reduce the death rate of Russels viper snake bite patients by using Antisnake venom.

Comparing the efficacy and safety of 36 hrs low dose Anti-Snake Venom regimen vs 72 hrs regimen in Russelâ??s viper hemotoxic envenomation - A randomised control trial. - SAVIOR

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/12/048418

Enrollment

200

Registered

2022-12-23

Start date

Unknown

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T630- Toxic effect of snake venom

Interventions

Intervention1: POLYVALENT ANTISNAKE VENOM: NOT APPLICABLE Intervention2: POLYVALENT ANTISNAKE VENOM REGIMEN 1: ARM 1 36 HOURS POLYVALENT ANTISNAKE VENOM THERAY FOR RUSSELS VIPER ENVENOMATION. Loading

Eligibility

Inclusion criteria

Inclusion criteria: (a) Patients aged >18 years with H/o bite by Russelâ??s viper [visually identified] (b) Presenting within 6 hours to our institute. (c) Clinical signs of systemic envenomation warranting ASV, and/or (d) Abnormal WBCT [ >20 minutes, incoagulable].

Exclusion criteria

Exclusion criteria: (a)Patients with CKD (b)Heart failure (c)Pregnancy (d)Age >65 years.

Design outcomes

Primary

Measure	Time frame
MORTALITYTimepoint: 28 DAY	—

Secondary

Measure	Time frame
1. Dosage of ASV needed 2. Time to normalization of WBCT 3. Time to normalization of PT/INR/APTT. 4. Time to clinical recovery 5. Time to hemodynamic stabilization 6. Need for FFP 7. Dosage of FFP needed 8. Duration of ICU stay. 9. Need for RENAL REPLACEMENT THERAPY 10. Need for Mechanical Vent Support [MVS] 11. Duration of MVS 12. Need for fasciotomy/ amputation. Timepoint: 28 DAY	—

Countries

India

Contacts

Public ContactSHIVKUMAR GOPALAKRISHNAN

GOVERNMENT VILLUPRAM MEDICAL COLLEGE AND HOSPITAL

gvmcforms123@gmail.com9600778303

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026