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To evaluate and compare the effects of injectable platelet-rich fibrin (i-PRF) which is a third generation platelet concentrate and micro-osteoperforation (MOP) also known as flapless bone puncturing on the rate of canine movement during retraction in patients requiring premolar extractions.

Evaluation and comparison of the effects of injectable platelet-rich fibrin (i-PRF) and micro-osteoperforation (MOP) on accelerated orthodontic tooth movement. A split-mouth prospective randomized controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048404
Enrollment
10
Registered
2022-12-22
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K039- Disease of hard tissues of teeth,unspecified

Interventions

Intervention1: Micro-osteoperforation: micro-osteoperforation to be done distal to canine space 8 days post extraction. MOP will be done on the buccal aspect distal to canine in the extraction space.

Sponsors

KUSHAL TAORI
Lead Sponsor
PRIYANKA NIRANJANE
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients age varying from 15 â?? 30 years having class 2 division 1 and bimaxillary protrusion that requires removal of both maxillary first premolars. 2. Patients with average growth pattern. 3. Patients with no systemic conditions and diseases. 4. Patients with fully erupted maxillary canine. 5. Patients with healthy periodontal parameters having no clinical attachment loss or PPD more than 2-3 mm. 6. Patients indicated for fixed orthodontic therapy.

Exclusion criteria

Exclusion criteria: 1. Patients with horizontal and vertical growth pattern. 2. Patients with developmental and congenital syndromes. 3. Patients with any systemic diseases like clotting disorders and conditions like pregnancy, anticoagulant therapy. 4. Patients above the age of 30 years. 5. Patients with deleterious habits like smoking are the subjects to be excluded. 6. Patients undergoing removal or myofunctional orthodontic treatment. 7. Patients on medication that decease orthodontic tooth movement like NSAIDS(Ibuprofen, aspirin, aceclofenac, diclofenac), bisphosphonates, hormonal replacement therapies.

Design outcomes

Primary

MeasureTime frame
Rate of canine retraction.Timepoint: At T1 T2 T3 T4 T1 - one week post extraction T2 - four weeks post extraction T3 - 8 weeks post extraction T4 - 12 weeks post extraction—

Secondary

MeasureTime frame
Pain assessment in both the groups.Timepoint: at T1 T2 T3 T4 where, T1 - one week post extraction T2 - four weeks post extraction T3 - 8 weeks post extraction T4 - 12 weeks post extractioon—

Countries

India

Contacts

Public ContactKUSHAL TAORI

DATTA MEGHE INSTITUTE OF MEDICAL SCIENCES (DMIMS)

drpriyankaniranjane@gmail.com9823449728

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026