To compare the efficacy of Opioid free analgesia with Magnesium sulphate and Ketamine versus opioid analgesia with Morphine in perioperative period for head and neck oncosurgeries by total intravenous anaesthesia technique.

Opioid free Total intravenous anaesthesia with Magnisium sulphate and Ketamine for perioperative analgesia in head and neck oncosurgeries.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/12/048378

Enrollment

Registered

2022-12-21

Start date

Unknown

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C06- Malignant neoplasm of other and unspecified parts of mouth

Interventions

Intervention1: Opioid free total intravenous anaesthesia with Magnesium sulphate and Ketamine .: Non opioid agents ,Magnesium sulphate(40mg/Kg loading dose 10minutes prior induction over 10 minutes i

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 OR 2 , undergoing elective head and neck oncosurgey.BMI between 18 to 35Kg/m2. who are ready to give written informed consent

Exclusion criteria

Exclusion criteria: Patient refusal , ASA 3 and 4 patients , pregnants ,lactating mothers ,deteriorating neurological disorders ,liver disease, renal disease ,cardiovascular disease with EF less than 40.known drug allergy.chronic pain on opioid or other analgesic .calcium channel blocker treatment

Design outcomes

Primary

Measure	Time frame
Perioperative analgesia. Timepoint: 0 hours to 48 hours of surgery.	—

Secondary

Measure	Time frame
intraoperative haemodynamic stability.Timepoint: 24 hours	—

Countries

India

Contacts

Public ContactDrSuvarna K

Government Medical College Kozhikode.

suvarnakaniyil@gmail.com9447638221

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026