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study to compare the effect of two antihypertensive drugs in control of severe hypertension in pregnancy

randomised comparative study of efficacy of iv labetalol vs oral nifedipine in acute control of severe hypertension in pregnancy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048332
Enrollment
100
Registered
2022-12-20
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O14- Pre-eclampsia

Interventions

Intervention1: Iv labetalol: Iv labetalol 20mg initially followed by accelerating doses of 40mg,80mg and 80mg every 20minutes until the target blood pressure is achieved Intervention2: Oral nifedipine

Sponsors

DR AISHWARYA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ALL ANTENATAL WOMEN WITH GESTATIONAL AGE >20 WKS WITH SEVERE PREECLAMPSIA. BP >160/110MMHG ON 2 SEPARATE OCCASIONS 30 MIN APART IN LATERAL RECUMBANT POSITION. WITH MATERNAL HEART RATE 60-120BPM.

Exclusion criteria

Exclusion criteria: HEART RATE 120BPM. PATIENTS WITH CARDIAC DISEASE,ASTHMA,HAEMOTOLOGICAL DISORDER,LIVER DISORDER OR DRUG RELATED ALLERGIES

Design outcomes

Primary

MeasureTime frame
To assess the effectiveness and safety of oral nifedipine and iv labetalol in terms of time taken to achieve target BP150/100mmhg. Number of doses required to achieve target BP150/100mmhg. Alternative drug requirement.Timepoint: every 20 minutes until the blood pressure is contolled—

Secondary

MeasureTime frame
To know about side effects of drugs . Maternal outcomes. Fetal outcomes.Timepoint: Look for side effects every 20minutes.—

Countries

India

Contacts

Public ContactDR MADHU J

KARNATAKA INSTITUTE OF MEDICAL SCIENCES

madhuobg@yahoo.co.in9480274753

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026