Health Condition 1: K135- Oral submucous fibrosis
Conditions
Interventions
Intervention1: Platelet rich plasma therapy: Autologous PRP 5ml will be given intralesionally in submucosal plane at multiple sites of palpable fibrous bands at about 0.5ml per 1cm2 using 25-gauge nee
Sponsors
Dr M Mary Sujatha
Eligibility
Inclusion criteria
Inclusion criteria: 1. The individuals who gave a positive history of Areca nut/ Ghutka / Betel Quid chewing. 2. The criteria for the presence of the disease according to clinical staging and clinical inspection:Burning sensation, the presence of fibrous bands, Restricted mouth opening. 3. Histologically proven oral submucous fibrosis.
Exclusion criteria
Exclusion criteria: 1 Patient with blood-borne diseases 2 Medically compromised patients 3 Anti-coagulant therapy 4 Immunosuppressive therapy 5 Critical thrombocytopenia (low platelet count) 6 Hypofibrinogenemia. 7 Hemodynamic instability 8 Individuals with history of any systemic disease and undergoing treatment. 9 Individuals not willing to be a part of study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To know efficacy of the each treatment modality Intralesional Injections, PRP injections, Laser therapy in Oral submucous fibrosis clinically in reduction of fibrous bands, burning sensation of mouth increase in mouth opening.Timepoint: 1. Reduction of fibrous bands: 1, 2, 3, 4, 5, 6 weeks and 3, 6, 9 months. 2. Reduction in burning sensation of mouth: 1, 2, 3, 4, 5, 6 weeks and 3, 6, 9 months. 3. Increase in mouth opening: 1, 2, 3, 4, 5, 6 weeks and 3, 6, 9 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
India
Contacts
Public ContactDr T Ramesh
Vishnu Dental College and Hospital
Outcome results
None listed