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A comparative study to determine the efficacy between Palonosetron and Aprepitant in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

A comparative study to determine the Efficacy between Palonosetron and Aprepitant in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048315
Enrollment
60
Registered
2022-12-20
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K80- Cholelithiasis

Interventions

Intervention1: Aprepitant: Group 1 patients will be receiving 80 mg of Aprepitant with 30 ml of water orally on the morning of the surgery before 90 mins in the ward and 5 ml of normal saline i.v imme

Sponsors

Pondicherry Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients belonging to American society of Anesthesiologist physical status 1 and 2. 2.Patients undergoing elective laparoscopic cholecystectomy. 3.Non-Smokers (including smokers who quit smoking for >6 months)

Exclusion criteria

Exclusion criteria: 1.H/o motion sickness 2.Obese patients (BMI > 30 Kg/m2) 3.Patients on oral steroids 4.Pregnant Womens 5.Previous H/o Postoperative nausea and vomiting 6.H/o Arrhythmias on medications.

Design outcomes

Primary

MeasureTime frame
To compare the incidence of Postoperative nausea and vomiting between intravenous Palonosetron and Oral Aprepitant in patients undergoing laparoscopic cholecystectomy.Timepoint: 24 hrs—

Secondary

MeasureTime frame
To compare the requirement of rescue antiemetics in between the two groupsTimepoint: 24 hrs—

Countries

India

Contacts

Public ContactSivakumar S

Pondicherry Institute of Medical Sciences

siva85dr@gmail.com9944060676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026