Skip to content

A study to evaluate blood levels of a hormone released from the heart (NT-pro-BNP) for determining need for closure of a blood vessel (Patent Ductus Arteriosus) in premature newborns.

Diagnostic accuracy of N-Terminal Pro-Brain Natriuretic Peptide for early patent ductus arteriosus closure in preterm neonates.

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/12/048305
Enrollment
50
Registered
2022-12-20
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P073- Preterm [premature] newborn [other]

Interventions

None listed

Sponsors

Vishal Vishnu Tewari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All preterm neonates <= 31 weeks period of gestation serially admitted to the NICU of Command hospital (WC), Chandimandir will be included in the study.

Exclusion criteria

Exclusion criteria: Neonates with major congenital malformations, symmetric Intrauterine growth restriction, any congenital heart diseases, gestation =32 weeks

Design outcomes

Primary

MeasureTime frame
To assess NT-pro-BNP for identifying preterm neonates at â?¤ 31 weeks gestation at risk for developing symptomatic patent ductus arteriosus necessitating pharmacologic closureTimepoint: To assess NT-pro-BNP for identifying preterm neonates at â?¤ 31 weeks gestation at risk for developing symptomatic patent ductus arteriosus necessitating pharmacologic closure

Secondary

MeasureTime frame
1. Correlate NT-pro-BNP levels with echocardiography markers of hemodynamically significant PDA (hs-PDA) 2. Compare NT-pro-BNP levels in preterm neonates with symptomatic PDA who underwent pharmacologic closure with those who had spontaneous closure of PDA 3. Incidence of mortality, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH) and retinopathy of prematurity (ROP) Timepoint: By day of discharge from the hospital

Countries

India

Contacts

Public ContactVishal Vishnu Tewari

Command Hospital (WC) Chandimandir

docvvt_13@hotmail.com091-8826118889

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026