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COMPARISON OF EFFICACY OF THREE ADJUVANT DRUGS ADRENALINE, CLONIDINE AND DEXMEDETOMIDINE WHEN USED WITH LIGNOCAINE HYDROCHLORIDE FOR LOCAL ANAESTHESIA FOR SURGICAL REMOVAL OF IMPACTED MANDIBULAR THIRD MOLAR

EVALUATION AND COMPARISON OF EFFICACY OF LIGNOCAINE HYDROCHLORIDE WITH ADRENALINE, CLONIDINE AND DEXMEDETOMIDINE WHEN USED FOR LOCAL ANAESTHESIA FOR SURGICAL REMOVAL OF IMPACTED MANDIBULAR THIRD MOLAR

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048281
Enrollment
45
Registered
2022-12-20
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: dexmedetomidine: Subjects requiring impacted third molar surgery with 1 dose of 2% Lignocaine Hydrochloride with 20 mcg/ml dexmedetomidine as the local anesthetic agent. Control Inte

Sponsors

Sharad Pawar Dental College And Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Individuals with ASA Gr I status 2) Individuals between 18 to 40 years 3) Presence of at least one asymptomatic impacted mandibular third molar having moderate to very difficult ,difficulty index ( Modified Pedersonâ??s Scoring )

Exclusion criteria

Exclusion criteria: 1. History of drug dependence 2. Patients with systemic disease such as HTN, DM, blood dyscrasias, immunocompromised status. 3. Patients who chronic smokers 4. Patients on cardio-selective antihypertensive drugs 5. Patients with allergy to local anesthetic agents used in the study 6. Pregnant and nursing mothers 7. Females on oral contraceptives 8. Patients undergoing treatment with antibiotics, anti-inflammatory drugs 9. Presence of any local infection like pericoronitis/pterygomandibular space infection 10. Presence of any chronic facial pain on the side of intervention 11. Radiologic evidence of Inferior alveolar canal approximation 12. Patients with Congenital Heart Disease. 13. Patients who are have any psychiatric illness.

Design outcomes

Primary

MeasureTime frame
1) Onset of anesthesia 2) Depth of anesthesia 3) Hemodynamic parameters 4) Duration of postoperative analgesiaTimepoint: at Baseline, after 30 minutes,after 1 hour

Secondary

MeasureTime frame
Hemodynamic parametersTimepoint: at Baseline, after 15 minutes, 30 minutes,60 minutes and 120 minutes

Countries

India

Contacts

Public ContactAkash Yogesh Doshi

datta meghe institute of medical sciences

drnitinbhola@gmail.com9970070607

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026