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To compare Effectiveness of two drugs Esmolol and Lignocaine for decreasing the Pressor Response during artificial tube insertion in respiratory tube under General Anaesthesia

Comparison of effectiveness of Esmolol and Lignocaine for Attenuating the Pressor response to Laryngoscopy and Endotracheal Intubation under General Anaesthesia:A Hospital Based Prospective Randomized double blind interventional study at sms Medical college Jaipur During 2021-2023

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048275
Enrollment
60
Registered
2022-12-19
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Attenuating the Pressor Response to Laryngoscopy and Endotracheal Intubation under General Anaesthesia: Attenuating the Pressor Response to Laryngoscopy and Endotracheal Intubation by u

Sponsors

Department of Anaesthesiology SMS MEDICAL COLLEGE AND HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex scheduled to undergo elective surgical procedures under general anesthesia and endotracheal intubation. Age 20 years to 50 years Weight 50 kg to 80 kg Patients of ASA grade 1 and 2. Patient willing to give the consent.

Exclusion criteria

Exclusion criteria: Patients with history of known allergic to study drugs.History of consumption of antihypertensive drugs, sedatives, Hypnotics and antidepressants preoperatively.Pre-existing cardiovascular disease, significant respiratory, renal and hepatic disorder.History of drugs or alcohol abuse. Pregnant patients Patients requiring rapid sequence induction of anaesthesia Anticipated difficult intubation

Design outcomes

Primary

MeasureTime frame
To determine the difference in changes in haemodynamic responses (heart rate, SBP, DBP, MAP) from baseline to different time interval in the two groups.Timepoint: 0, 1,2,3,4,5,10,15 min after intubation—

Secondary

MeasureTime frame
To determine the difference in percentage in cases who develop side effect in both group.Timepoint: upto 24 hours of extubation—

Countries

India

Contacts

Public ContactDr Ravindra Dhanopiya

SMS Medical College and Hospital Jaipur Rajasthan

suncha87@yahoo.co.in9414077324

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026