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Assessment of Biological markers which indicate resorption of roots of teeth during orthodontic treatment

Assessment of Specific Protein Biomarkers in the Gingival Crevicular Fluid for the detection of orthodontically-induced inflammatory external root resorption in patients undergoing comprehensive orthodontic treatment - A Prospective Cohort Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/12/048229
Enrollment
20
Registered
2022-12-19
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R90-R94- Abnormal findings on diagnostic imaging and in function studies, without diagnosis Health Condition 2: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

None listed

Sponsors

MES Dental College, Perinthalmanna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with Angleââ?¬•s Class I malocclusion with bimaxillary dentoalveolar protrusion who need extraction of maxillary 1st premolars followed by comprehensive orthodontic treatment. 2. Age group between 15-25 years,with complete root formation; gender distribution will be equal. 3. Normal vertical dimension represented by GoGn-SN of 32+6Ã?°.

Exclusion criteria

Exclusion criteria: 1.Patients taking systemic steroids, anti-inflammatory medications, or medications with xerostomic effects. 2.Clinical signs of periodontal disease upon visual intraoral inspection, non-vital teeth,impacted/supernumerary teeth/history of trauma 3.Asthmatic patients/any systemic diseases 4.History of previous orthodontic treatment or Radiographic evidence of apical root resorption. 5.Oral Habits, smokers

Design outcomes

Secondary

MeasureTime frame
1.To evaluate external root resorption using metric measurements as well as grading root resorption. 2.To evaluate the relation if any between root resorption and age, gender and duration of treatment.Timepoint: To-Prior to start of orthodontic treatment T1-At the start of retraction T2-3months following the start of retraction T3-At the end of retraction—

Primary

MeasureTime frame
Quantification of specific protein biomarkers (CEMP-1, DSPP and MMP-9) in gingival crevicular fluid at different clinical time-points utilizing ELISA and its relation to the severity of Orthodontic root resorption as measured on RVG.Timepoint: To-Prior to start of orthodontic treatment T1-At the start of retraction T2-3months following the start of retraction T3-At the end of retraction—

Countries

India

Contacts

Public ContactDr Vincy Antony

MES Dental College, Perinthalmanna, Kerala

vincyantony2008@yahoo.com9846353153

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 27, 2026