Health Condition 1: I501- Left ventricular failure, unspecified Health Condition 2: O- Medical and Surgical Health Condition 3: I978- Other intraoperative and postprocedural complications and disorders of the circulatory system, not elsewhere classified
Conditions
Interventions
Intervention1: Vasopressin: Infusion dose - 1 Unit/ ml
Route- Intravenous
Frequency- 1.2 ml/hour started after completion of loading dose of milrinone
Duration- 24 hours post surgery
Control Intervent
Sponsors
Postgraduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Planned for elective cardiac surgery with CPB and presenting with LV dysfunction preoperatively. LV dysfunction will be identified by the presence of LV EF < 50% on the last available preoperative echocardiography report, except in patients with severe mitral regurgitation where the cutoff for LV EF will be <60%.
Exclusion criteria
Exclusion criteria: Preoperative requirement of vasopressors/inotrope/mechanical circulatory support Pregnancy Patients undergoing simultaneous non cardiac surgery Patients on renal replacement therapy Patients with model for end-stage liver disease Patients taking drugs for thyroid or adrenal disease Documented peripheral vascular disease disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac indexTimepoint: 30 minutes post cardiopulmonary bypass | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate, blood pressure, inotrope dose, blood gas investigations, cardiac index, left ventricle myocardial performance index, left ventricle systolic, diastolic functionTimepoint: Baseline, 30 minutes post CPB, and 0, 6, 12 and 24 hours in ICU;Hospital stay, MortalityTimepoint: 30 days post-operatively;Mechanical ventilation duration, ICU stay, Incidence of atrial fibrillation, requirement of renal replacement therapy, incidence of acute mesentric ischemia, peripheral cyanosisTimepoint: During ICU stay | — |
Countries
India
Contacts
Public ContactRajarajan Ganesan
Postgraduate Institute of Medical Education and Research
Outcome results
None listed