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Topical Methotrexate in the Treatment of patches of Hair Fall

Comparitive Evaluation of Efficacy, Safety,and Cost Effectiveness of Topical Betamethasone with Tretinoin VS Methotrexate with Tretinoin in Patients of Alopecia Areata: A Prospective Randomised Double Blind Study

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048063
Enrollment
80
Registered
2022-12-13
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L638- Other alopecia areata

Interventions

Intervention1: Topical Betamethasone 0.05% with Topical Tretinoin 0.025%: Patients will be asked to apply Topical Betamethasone 0.025% once every 24hours in the morning for 3 months with Topical Treti

Sponsors

Vaibhav Vivek Kalgaonkar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of Alopecia Areata of at least 2 months duration Patients having patches in 1-3 numbers over the scalp. Patients who are willing to take part in the study with signed and written informed consent. Patients could be of both male and female. All patients who are 18 years and above of age Patient must be medically stable. Patient must have active mobile number.

Exclusion criteria

Exclusion criteria: Patients who are not willing to sign in after informed consent. Pregnant, breast feeding, child bearing age using contraception. Patient with Alopecia Totalis and Alopecia Universalis Patient with a K/C/O any Autoimmune conditions like SLE, Thyroid disorder, Vitiligo, etc. Patient receiving systemic treatment relevant to alopecia areata within 3 months of enrollment. Patient receiving Topical treatment relevant to Alopecia areata within 2 months Patient with any Fungal infection of scalp Patient with dermatological conditions affecting skin other than Alopecia Areata. Patient with psychiatric illness or psychological state interfering with compliance

Design outcomes

Primary

MeasureTime frame
To Observe the Effect of Test Drugs on Hair Regrowth in the patients of Alopecia Areata using Alopecia Grading Scale (AGS) and Alopecia Regrowth Score (RGS). To compare the efficacy between both the groups Timepoint: Baseline on the day of enrollment 1st,2nd and 3rd month

Secondary

MeasureTime frame
To check any adverse effects of the the test drugsTimepoint: End of 1st, 2nd and 3rd month

Countries

India

Contacts

Public ContactVaibhav Vivek Kalgaonkar

Gajra Raja Medical College Gwalior Madhya Pradesh

saroj.kothari@rediffmail.com9827322002

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026