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Prevention of change of gastric Ph(acidity) and volume during laparoscopic cholecystectomy(removal of diseased gall bladder due to gall stone disease) by intravenous rabeprazole(Antacid)in patients during general anaesthesia to minimize risk of gastric aspiration and injury to lungs

Effectiveness Of Rabeprazole Premedication on Gastric Fluid Ph and Volume Change in Patient Undergoing Laparoscopic Cholecystectomy

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/12/048045
Enrollment
30
Registered
2022-12-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis

Interventions

Intervention1: Effectiveness of intravenous rabeprazole premedication on gastric fluid pH and volume change in patients undergoing laparoscopic cholecystectomy: GROUP-B Study group Patients receiving

Sponsors

VCSGGMS and RI Srikot Srinagar Garhwal Uttarakhand
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient with American Society Of Anaesthesia Grade 1 and 2 undergoing laproscopic cholecystectomy under general anaesthesia

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA- Patient with gastric reflux, peptic ulcer hiatal hernia,liver disease with deranges liver function, hypersensitivity to pantoprazole will be excluded from study.

Design outcomes

Primary

MeasureTime frame
A)To study effect/ action of intravenous rabeprazole on gastric pH and volume during laparoscopic cholecystectomy. Timepoint: The gastric aspirates for pH (3ML) and volume and measurement will be collected through Ryle’s tube (16G).Colour of samples will be noted. i) At the end of 8 hrs of fasting period before inj rabeprazole-TIME-0 ii) Post Induction 5minutes Before CO2 insufflation iii) 5 minutes Post CO2 Inflation than Half hrly perioperatively iV) Post CO2 deflation 5 ,10 ,15minuts and 30 minutes perioperatively V) I/2 hr & 1hr after extubation.

Secondary

MeasureTime frame
Incidence of Perioperative duodenal gastric regurgitation during laparoscopic cholecystectomy C)Postoperative nausea vomiting Timepoint: i)At the end of fasting period before inj rabeprazole ii)Post Induction Before CO2 insufflation iii)Post CO2 Inflation Halfhrly perioperatively iV)Post CO2 deflation perioperatively V)1/2 hr & 1hr after extubation.

Countries

India

Contacts

Public ContactDr Satyendra Yadav

Department Of Anaesthesia VCSGGMS and RI

satyendra.homein@gamil.com9410110479

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026