To compare the brain activity of patients wearing complete dentures with fixed dentures.

A comparative evaluation of brain function activity in different prosthodontic treatment modalities, employing Functional Magnetic Resonance Imaging(fMRI), Electroencephalogram(EEG) and Active Tactile Sensibility(ATS) - an in vivo study

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/12/047872

Enrollment

Registered

2022-12-05

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K068- Other specified disorders of gingiva and edentulous alveolar ridge

Interventions

Intervention1: Implant-supported prosthesis: Implant-supported prosthesis may include implant-supported over dentures, implant- supported fixed denture. the parameters for osseointegration and brain f

Eligibility

Inclusion criteria

Inclusion criteria: 1. Completely edentulous arch or non-restorable remaining teeth. 2. No acute infection is present. 3. Without any history of temporomandibular joint disorders, psychiatric disorders or neurophysiology modifying medication. 4. Patient’s cooperation, motivation and good oral hygiene 5. Informed consent

Exclusion criteria

Exclusion criteria: 1. Uncontrolled systemic disorders 2. Patients with a smoking habit and a history of alcoholism 3. Bruxism and any other parafunctional habits like clenching, tongue thrusting, etc. 4. Active chemotherapy or active radiotherapy 5. Use of medications with known neuromotor effects, e.g., neuroleptics or antidepressants.

Design outcomes

Primary

Measure	Time frame
1. increased brain function activity in functional magnetic resonance imaging following prosthetic rehabilitation after 1 month. 2. increased alpha wave amplitude in electroencephalogram following prosthetic rehabilitation after 1 month.Timepoint: 1. increased brain function activity in functional magnetic resonance imaging following prosthetic rehabilitation after 1 month. 2. increased alpha wave amplitude in electroencephalogram following prosthetic rehabilitation after 1 month.	—

Measure

Time frame

1. increased brain function activity in functional magnetic resonance imaging following prosthetic rehabilitation after 1 month. 2. increased alpha wave amplitude in electroencephalogram following prosthetic rehabilitation after 1 month.Timepoint: 1. increased brain function activity in functional magnetic resonance imaging following prosthetic rehabilitation after 1 month. 2. increased alpha wave amplitude in electroencephalogram following prosthetic rehabilitation after 1 month.

—

Secondary

Measure	Time frame
increased active tactile sensibility following prosthetic rehabilitation after 1 month.Timepoint: 1 month then 4 months	—

Countries

India

Contacts

Public ContactAtul Bhatnagar

Faculty of dental sciences, IMS, BHU

atuldent@hotmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026