The study is to compare the two groups of drugs for prevention of vomiting after surgery

A comparative study of Granisetron and Dexamethasone combination against Ondansetron and Dexamethasone combination for prevention of post-operative nausea and vomiting in middle ear surgeries

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/12/047871

Enrollment

134

Registered

2022-12-05

Start date

Unknown

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H661- Chronic tubotympanic suppurative otitis media Health Condition 2: H673- Otitis media in diseases classified elsewhere, bilateral Health Condition 3: H679- Otitis media in diseases classified elsewhere, unspecified ear

Interventions

Intervention1: Intraoperative intervention for prevention of post operative nausea and vomiting: Injection dexamethasone given before intubation in both groups and injection Ondansetron and Granisetro

Eligibility

Inclusion criteria

Inclusion criteria: ASA I,II with 20 to 65yrs both male and female are selected who are posted for Middle ear surgeries

Exclusion criteria

Exclusion criteria: Pregnancy, patient with BMI >35, smokers, history of PONV/motion sickness, abnormal liver and kidney function test, patient with Diabetes and peptic ulcer are excluded from the study

Design outcomes

Primary

Measure	Time frame
The incidence of PONV and rescue antiemetic requirements in granisetron and dexamethasone group is less than ondansetron and dexamethasone groupTimepoint: Time points at which variables are measured are 0hr, 2hr, 6hr, 12hr & 24hr postoperatively	—

Secondary

Measure	Time frame
Rescue antiemetic requirements Rescue analgesic requirementsTimepoint: Within 48 hour of post-operative period	—

Countries

India

Contacts

Public ContactShantanu Das

VIMSAR, BURLA

patelmalaya@gmail.com9937756618

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026