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role of hypertonic saline versus mannitol in reducing cerebral edema in children

To study the role of 3% hypertonic saline and mannitol in the reduction of raised intracranial pressure in children

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047736
Enrollment
90
Registered
2022-11-28
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G936- Cerebral edema

Interventions

Intervention1: 3% hypertonic saline: initial loading of 10ml/kg intravenous followed by 0.1ml/kg/hr will be done and compared to mannitol. Control Intervention1: mannitol: initial loading dose of 0.5g

Sponsors

departement of pediatrics
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: patients with signs of raised intracranial pressure

Exclusion criteria

Exclusion criteria: 1. Children with gross congenital anomaly. 2. Hospital stay less than 8 hours. 3. Referred patient who has already recieved any hyperosmolar agent from outside.

Design outcomes

Primary

MeasureTime frame
duration of comaTimepoint: 72 hours—

Secondary

MeasureTime frame
mortality complicationsTimepoint: duration of hospital stay—

Countries

India

Contacts

Public ContactDr Nanni Slathia

Department of pediatrics government medical jammu

drrazaq.razaq@gmail.com9419124809

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026