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CT Image Based Closest-to-tumor Radiation in Cervical Cancer

A Prospective Observational Study on CT Image Based Adaptive Brachytherapy in Locally Advanced Cervical Cancer Patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/11/047633
Enrollment
60
Registered
2022-11-24
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C538- Malignant neoplasm of overlappingsites of cervix uteri

Interventions

None listed

Sponsors

Chittaranjan National Cancer Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients of cervical cancer sent from multidisciplinary tumor board after being proved on histopathology (squamous cell or adenocarcinoma) with FIGO stage IB2 to III 2.Eastern Cooperative Oncology Group performance status upto 2 3.Hemoglobin >10 gm%, Total leukocyte count > 4000 cells/cmm, Platelet count > 1,00,000 cells/cmm (initially or after correction by blood transfusion). 4.Liver function test- AST Kidney function test- Serum creatinine 50 ml/min 5.Patient with no history or current clinical evidence of any hematological or bleeding disorders 6.No history of drug use which results in hematological toxicity 7.HBsAg, Anti-HCV, HIV-I & -II Antibody non-reactive patients.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
To assess the feasibility of delineating HR-CTV on CT image following IBS-GEC ESTRO-ABS recommendations & Pre- & Post-EBRT MRI images. Computation of target coverage along with the doses received at Point A. To compare the doses received by bladder, rectum & bowel as per volume-based dose prescription and Point A-based dose prescription. Timepoint: At baseline

Secondary

MeasureTime frame
To assess the treatment response & toxicity with special attention to Gastrointestinal (GI) & Genitourinary(GU) toxicity. Timepoint: At baseline,4 weeks,8weeks,12 weeks,6months,yearly

Countries

India

Contacts

Public ContactDebarshi Lahiri

Chittaranjan National Cancer Institute

dandapatadhiraj@gmail.com9932711670

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026