Health Condition 1: F314- Bipolar disorder, current episodedepressed, severe, without psychotic features Health Condition 2: F332- Major depressive disorder, recurrent severe without psychotic features Health Condition 3: F322- Major depressive disorder, singleepisode, severe without psychotic features
Conditions
Interventions
Intervention1: Intravenous Ketamine hydrochloride: Patients will be premedicated with injection Glycopyrrolate(0.004mg/kg) IV following which they will receive infusion of Ketamine hydrochloride (0.5
Sponsors
KLES ACADEMY OF HIGHER EDUCATION AND RESEARCH
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged between 18 years to 65 years with 1. ICD-10 DCR diagnosis of a. Severe Depressive Episode without psychotic symptoms. b. Bipolar affective disorder, current episode severe depression without psychotic symptoms. c. Recurrent Depressive disorder, current episode severe depression without psychotic symptoms. 2. Availability of an informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe depression with psychotic symptoms. 2. Primary psychotic disorder. 3. Mixed episode 4. Intellectual Disability 5. Dementia 6. Mood disorder due to general medical conditions. 7. Hypertension (with B.P. > 140/90 mmHg) 8. Glaucoma 9. History of seizures, raised intracranial tension 10. Pregnant and lactating females. 11. Serious medical condition. 12. Substance dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 50% reduction in 17-item Hamilton Depression rating Scale, over a course of 3 interventions done 48 hours apartTimepoint: day 2, day 4, day 6 | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in 17-item Hamilton Depression rating Scale, 24 hours after interventionTimepoint: Day 2, Day 4, Day 6 | — |
Countries
India
Contacts
Public ContactAkanksha Ayushi Singh
KLEs Dr. Prabhakar Kore Hospital and Medical Research Centre
Outcome results
None listed