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A study to measure and compare amounts of proteins-S100A8/9,S100A8 and S100A9 in oral fluids of persons with periodontal health and disease in order to evaluate the potential of these proteins as markers of current periodontal disease activity.

Expression of S100A8/9,S100A8 and S100A9 among periodontal health and disease-A Clinical and Biochemical study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/11/047620
Enrollment
150
Registered
2022-11-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: NIL: NIL Intervention2: nil: Non surgical periodontal therapy is the standard first line of treatment for all patients presenting with periodontal diseases. In this study, patients with

Sponsors

Dr Annie Kitty George
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy non-smoking subjects consenting for the study in the age group of 25 -55 years. Patients satisfying criteria for periodontal health (PH), Gingivitis and stage 1 periodontitis(G) and stage 3 and 4 periodontitis(P).

Exclusion criteria

Exclusion criteria: Subjects with history of systemic co-morbidities such as cardiac conditions, diabetes mellitus, hepatic or renal impairments. Antibiotic treatment in the preceding 3 month Pregnant and lactating females Patients presenting with multiple intra oral abscesses and suppuration which necessitates antibiotic therapy.

Design outcomes

Primary

MeasureTime frame
Differences in expression of S100A8/A9,S100A8 and S100A9 in saliva and gingival crevicular fluid(GCF), among participants with periodontal health(H),Gingivitis and stage 1 periodontitis(G) and stage 3 and 4 periodontitis(P) Change in salivary and GCF levels of S100A8/9,S100A8 and S100A9 in the stage 3 and 4 periodontitis group(P),after non-surgical periodontal therapy(NSPT) at patient recall visit scheduled four weeks after NSPTTimepoint: At baseline and at 4 weeks after NSPT—

Secondary

MeasureTime frame
Differences in clinical periodontal parameters Plaque Index (PI- Silness and Loe,1964), Gingival Index (GI-Loe and Silness,1963), Probing pocket depth (PPD), Clinical attachment loss (CAL) and Periodontally Inflamed Surface Area (PISA) between participant groups. Changes in these clinical parameters following non-surgical periodontal therapyTimepoint: Base line and four weeks after non-surgical periodontal therapy—

Countries

India

Contacts

Public ContactDr Sankri M

PhD Guide

msankari@gmail.com9840285905

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026