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Use of multiple drugs to reduce pain of propofol injection

To compare the effect of Lignocaine, Ondansetron, Ramosetron and Metoclopramide in attenuation of propofol induced pain during the induction of anaesthesia

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047602
Enrollment
200
Registered
2022-11-24
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous Ondansetron: Single dose of intravenous ondansetron 4mg duration of intervention is 30 seconds Intervention2: intravenous ramosetron: Single dose of intravenous ramosetron 0

Sponsors

Mysore Medical college and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective surgeries under general anaesthesia. 2. Belonging to American Society of Anaesthesiologists (ASA) Physical status I or II. 3. Patients who are willing to sign written informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients belonging to ASA III and IV physical status. 2. Patients with known cardiac disorders, other systemic disorders of lung and liver. 3. Pregnant patients 4. Patients for emergency procedures. 5. Those allergic to Propofol and study drugs 6. Those with history of motion sickness 7. History of post- operative nausea and vomiting 8. Patients in nasogastric tube and patients with difficult airway. 9. Patient refusal 10. History of taking any analgesic before surgery 11. Neurological deficit

Design outcomes

Primary

MeasureTime frame
Attenuation of propofol induced pain during induction of anaesthesia.Timepoint: Pain is assessed at baseline, 5 seconds 10 seconds, 15 seconds, 20 seconds, 25 seconds and 30 seconds during induction of anaesthesia using propofol injection

Secondary

MeasureTime frame
nilTimepoint: nil

Countries

India

Contacts

Public ContactDr Syeda Gowsia Azhar

Mysore Medical College and Research Institute

drsrinivasvy@gmail.com9448165082

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026