FindTrial
Sign In

comparision of melatonin and olanzapine in prevention and treatment of delirium in elderly male undergoing arthroplasty of hip or knee under neuraxial block

â??Assessment and comparison of efficacy of oral melatonin versus oral olanzapine versus oral placebo for prevention and treatment of post operative delirium in elderly patient after arthroplasty of hip or knee under neuraxial block: A three arm, double blinded, randomised control trial.â??

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047545
Enrollment
90
Registered
2022-11-23
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F05- Delirium due to known physiological condition Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: drug administration: comparison of efficacy of oral melatonin versus oral olanzapine versus oral placebo for prevention and treatment of post operative delirium in elderly patient after

Sponsors

S NIJALINGAPPA MEDICAL COLLEGE AND HSK HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients belonging to ASA I II III. 2 Aged 60 years or more. 3 Patients undergoing hip or knee arthroplasty under neuraxial block.

Exclusion criteria

Exclusion criteria: 1 Dementia. 2 Patient on Antipsychotic drugs. 3 ASA 4. 4 Patients with AMT (abbreviated mental test) score 5 Patients receiving intra operative midazolam or pentazocine.

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of oral melatonin, oral olanzapine and oral placebo(multivitamin) for prevention and treatment of post operative delirium in elderly patient after arthroplasty of hip or knee under neuraxial blockTimepoint: 7 days—

Secondary

MeasureTime frame
To estimate the proportion of post operative delirium and to notify the side effects of drugs used in postoperative delirium.Timepoint: 7 days—

Countries

India

Contacts

Public ContactDr Pavithra R

S Nijalingappa Medical College, Bagalkot-587102

shilpamasur@gmail.com9844117959

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026