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Leucine-rich alpha-2 glycoprotein (LRG) levels in the gingival crevicular fluid of periodontally healthy and periodontitis patients.

Evaluation and Comparison of Leucine-rich alpha-2 glycoprotein (LRG) in gingival crevicular fluid of periodontally healthy and Stage 1 Grade A periodontitis subjects and its response to nonsurgical periodontal treatment : A clinico-biochemical Interventional Study.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047543
Enrollment
50
Registered
2022-11-23
Start date
Unknown
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Scaling and Root planing, Oral hygiene instructions: All patients with Stage 1 Grade A will be treated with scaling and root planing in a single sitting followed by Oral hygiene instruc

Sponsors

T.P.C.Ts Terna Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Subjects between the age group of 26 to 49 years. Subjects who have not received periodontal therapy, in the previous six months. Subjects who readily give informed consent for the study. subjects with gingival index 0, clinical attachment level 0 will be included as periodontally Healthy. Subjects with gingival index greater than and equal to 1, maximum pocket probing depth less than and equal to 4mm, mostly horizontal bone loss, clinical attachment level 1-2 mm affecting less than and equal to 30% teeth involved with radiographic bone loss extending to the coronal-third (less than 15%) and no teeth loss due to periodontitis will be included as stage 1 grade A periodontitis.

Exclusion criteria

Exclusion criteria: Patients with any systemic disorders Patients with a history of smoking Pregnant and lactating females. Patients who have received any periodontal treatment in the previous 6 months Subjects who have received antibiotics, anti-inflammatory drugs or any other drugs within 6 months.

Design outcomes

Primary

MeasureTime frame
1.To determine the levels of LRG in gingival crevicular fluid of periodontally healthy patients. 2.To determine the levels of LRG in gingival crevicular fluid of stage 1 grade A periodontitis patient. 3. To compare levels of LRG in gingival crevicular fluid of periodontally healthy and stage 1 grade A periodontitis patient. 4. To correlate effect of scaling and root planning on level of leucine-rich alpha 2 glycoprotein (LRG) in gingival crevicular fluid in stage 1 grade A periodontitis patientsTimepoint: At baseline and at 6 weeks

Secondary

MeasureTime frame
To correlate between clinical parameters like plaque index, Gingival Index, Probing Depth, Clinical Attachment Levels, Bleeding On Probing and levels of leucine-rich alpha-2 glycoprotein (LRG) in gingival crevicular fluid.Timepoint: at baseline and plaque index, Gingival Index, Probing Depth, Clinical Attachment Levels, Bleeding On Probing at 6 weeks in stage 1 grade A periodontitis in patients.

Countries

India

Contacts

Public ContactDr Neha Surve

Terna Dental College

rohitshah17@gmail.com09699860609

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026