Health Condition 1: K652- Spontaneous bacterial peritonitis
Conditions
Interventions
Intervention1: CEFOPERAZONE SULBACTAM: INTERVENTION ARM will receive 1.5 gram of intravenous Cefoperazone sulbactam twice a day for 7 days
Control Intervention1: CEFTRIAXONE: COMPARATOR ARM will recei
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: Cirrhosis patients, in whom there is a clinical suspicion of SBP or ascitic fluid has more than 250 polymorphonuclear cells on microscopy will be included in this study.
Exclusion criteria
Exclusion criteria: Following patients will be excluded Secondary bacterial peritonitis Peritonial tuberculosis Patient with hepto cellular carcinoma Previous cultures positive for resistant bacteria to third generation cephalosporins Allergy to third generation cephalosporin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To compare early resolution rates of SBP after 48 hours of antibiotic administration between the two groups 2. To compare the resolution rates of SBP after 7 days of antibiotic administration between the two groupsTimepoint: 48 hours and 7 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the proportion of patients who develop new organ failure at 48 hours in the two groups using SOFA Score 2. To compare the mortality rates between the two groups at 30 and 90 days 3. To compare the length of hospital stay between the two groupsTimepoint: 48 hours, 30 days, 90 days | — |
Countries
India
Contacts
Public ContactSRIDHARA K
JIPMER
Outcome results
None listed