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Semaphorin 4D (SEMA4D) levels in saliva of periodontally healthy and periodontitis patients.

Evaluation and comparison of Semaphorin 4D (SEMA4D) levels in saliva of periodontally healthy and Stage 1 Grade A periodontitis patients and its response to non-surgical periodontal treatment: A clinico-biochemical interventional study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047486
Enrollment
50
Registered
2022-11-21
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Scaling and root planing, Oral hygiene instructions: All patients with Stage 1 grade A periodontitis will be treated with scaling and root planing in a single sitting followed by oral

Sponsors

Terna Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Individuals with good general health and age between 18-60 years. 2. Subjects who have not received periodontal therapy, in the previous six months. 3. Subjects who readily give informed consent for the study. 4. Systemically healthy patients. 5. Subjects with gingival index 0, plaque index 0, clinical attachment level 0 will be included as periodontally healthy. 6. Subjects with gingival index greater then or equal to 1, pocket probing depth less then or equal to 4mm, mostly horizontal bone loss, clinical attachment level 1-2 mm affecting less then or equal to30% teeth involved with radiographic bone loss extending to the coronal-third and no teeth loss due to periodontitis will be included as Stage 1 grade A periodontitis.

Exclusion criteria

Exclusion criteria: Consumption of tobacco in any form and alcoholics. 2. Pregnant and lactating females. 3. Subjects who have received anti-inflammatory, antibiotic and steroid drugs in previous three months.

Design outcomes

Primary

MeasureTime frame
1.To determine the level of SEMA4D in saliva of periodontally healthy patients. 2.To determine the level of SEMA4D in saliva of Stage 1 Grade A periodontitis. 3.To compare the level of SEMA4D in saliva of periodontally healthy and Stage 1 Grade A periodontitis. 4.To compare salivary levels of Semaphorin 4D (SEMA4D) before and after scaling and root planing in Stage 1 Grade A periodontitis patients. Timepoint: At baseline and at 4 weeks—

Secondary

MeasureTime frame
1. To correlate salivary levels of Semaphorin 4D (SEMA4D) with clinical parameters like Plaque Index (PI), Gingival Index (GI),Probing Depth (PD), Clinical Attachment Level (CAL) and Bleeding on Probing (BOP).Timepoint: At baseline and at 4 weeks—

Countries

India

Contacts

Public ContactDr Bela Nagasmal Khobragade

Terna Dental College Hospital

drdipikamitra@gmail.com9820180406

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026