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A study of skin protection dysfunction and infection indicators in psoriasis

A case control study of inflammatory and skin barrier dysfunction markers in chronic plaque psoriasis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/11/047473
Enrollment
50
Registered
2022-11-21
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L400- Psoriasis vulgaris

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Dr Safeera Abdul Khadar
Lead Sponsor
DrYashodhar P Bhandary
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: CASES: All consenting adult patients (age 18 years to 60 years) visiting Yenepoya medical college hospital who are diagnosed to have Chronic plaque psoriasis. CONTROLS: Age and gender matched healthy volunteers

Exclusion criteria

Exclusion criteria: FOR CASES AND CONTROLS: Patients with inflammatory and infectious diseases, diabetes, pre-existing cardiovascular disease, hypertension, malignancies, pregnancy and lactation Ongoing systemic therapy in the last 3 months or topical steroid therapy for last 2 weeks

Design outcomes

Primary

MeasureTime frame
Levels of mRNA expression of interleukins and tight junction proteins expressed in the skin of chronic plaque psoriasisTimepoint: Baseline at the time of visit

Secondary

MeasureTime frame
Correlation of the psoriasis disease severity with the levels of interleukins and barrier dysfunction markers. This will widen the knowledge about new targeted therapiesTimepoint: Baseline at the time of visit

Countries

India

Contacts

Public ContactSafeera Abdul Khadar

Yenepoya Medical College

malcolmpinto@gmail.com9916293106

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026