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To assess the effect of blood fraction on cell growth on human tooth root surfaces after cleaning

Comparative Evaluation of Human Periodontal Ligament Fibroblast Adhesion, Morphology and Proliferation on Debrided Periodontally Involved Root Surfaces Treated With or Without Plasma Rich in Growth Factors - An Ex Vivo Scanning Electron Microscope Study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047418
Enrollment
96
Registered
2022-11-18
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: K053- Chronic periodontitis

Interventions

Intervention1: Group A : Root samples treated with scaling and root planing alone.: Group A:Extracted periodontally involved root surfaces treated with scaling and root planing alone. Control Interv

Sponsors

MGM Dental College and Hospital Kamothe Navi Mumbai
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: for teeth 1. Single rooted extracted teeth, anterior to the premolar, affected with periodontitis with minimum of 5mm attachment loss with hopeless prognosis indicated for extraction. For blood 1. Healthy male donor aged 18-25 years rendering informed consent to participate in the study with a hemogram with all parameters within normal range.

Exclusion criteria

Exclusion criteria: For teeth:- 1. Teeth with root caries. 2. Teeth with non-carious cervical lesions 3. Teeth with endodontic treatment. 4. Teeth with root restorations. 5. Teeth that are acid etched or having bonded restorations. 6. Teeth with developmental anomalies. 7. Teeth having been subjected to vital/non vital bleaching. 8. Teeth with internal / external resorption. 9. Subjects having undergone nonsurgical / surgical periodontal therapy. For Blood:- 1. Diabetes 2. Hypertension 3. History of drug abuse 4. Tobacco chewing/ Smokers 5. Use of antiplatelet and anticoagulant drugs 6. History of bleeding and coagulation disorders 7. History of quantitative and qualitative platelet function disorders 8. History of Liver disease 9. Alcohol consumption 10. Use of anti-inflammatory drugs- NSAIDS 11. Recent history of febrile illness 12. Ongoing Pregnancy and Nursing mothers

Design outcomes

Primary

MeasureTime frame
The count, morphology and mitotic activity of fibroblast assessed through SEM analysis and MTT assay respectively is seen more on periodontally involved root surfaces treated with scaling and root planing and plasma rich in growth factors as compared to periodontally involved root surfaces treated with scaling and root planing alone.Timepoint: At baseline, At day 1 from baseline, At day 3 from baseline, and at day 7 from baseline.—

Secondary

MeasureTime frame
noneTimepoint: none—

Countries

India

Contacts

Public ContactDr Shruti Mhatre

MGM Dental College And Hospital, Kamothe, Navi Mumbai.

drvinkin@gmail.com9769804390

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026