Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: IV 0.9% Saline: Group A1 (Fentanyl Group) will receive 100 ml 0.9% saline infused intravenously over 15 minutes after anaesthetic induction and endotracheal
intubation.
Intervention2:
Sponsors
Sir Ganga Ram Hospital
Eligibility
Inclusion criteria
Inclusion criteria: BMI - 18.5 - 27.5 kg/m2 ASA Grade - 1 & 2
Exclusion criteria
Exclusion criteria: 1. Inability to obtain informed consent 2. Patient scheduled for emergency surgery 3. Pregnancy 4. Morbid obesity 5. Severe cardiac dysfunction 6. History of hypersensitivity of local or systemic anesthetic agents 7. Patients receiving beta-blockers or calcium channel blockers 8. Pacemaker in-situ 9. Deranged hepatic function 10. Deranged renal function 11. Deranged endocrine function 12. Known allergy to magnesium sulphate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is to measure the difference in HR and SBP at prespecified time points in patients receiving IV magnesium sulphate with fentanyl versus IV fentanyl alone. Timepoint: Specified time points will be as follows: i. T0 - At the time of skull pin insertion ii. T1, T3, T5, T7, T10, T15 â?? At 01, 03, 05, 07, 10 and 15 minutes after skull pin insertion respectively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measure the requirement of rescue medication (IV lignocaine 1.5 mg/kg) in patients showing 20% increase in HR and SBP at 01 and 03 minutesTimepoint: 1 minute (T1) after skull pin insertion 3 minute (T3) after skull pin insertion | — |
Countries
India
Contacts
Public ContactDr Rachna Bhutani
Sir Ganga Ram Hospital
Outcome results
None listed