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Program of enhanced infection control and prevention (IPC) guided by active and passive surveillance for carbapenem- and colistin-resistant Gram-negative organisms

Global Action in Healthcare Network (GAIHN) - Antimicrobial Resistance, India, Enhanced infection control and prevention driven by targeted surveillance - GAIHN

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/11/047361
Enrollment
9600
Registered
2022-11-16
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A499- Bacterial infection, unspecified

Interventions

None listed

Sponsors

US Centers for Disease Control and Prevention
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Component 1 (passive surveillance) Passive surveillance will occur for cultures sent from designated wards. All GN isolates found to be CRO by local standard of care AST may be included. Component 2 (active surveillance) Patients will be considered for inclusion in active surveillance who are identified as part of a contact investigation for an index case of a critical CRO or possible nosocomial transmission event or are admitted to a ward designated for universal active surveillance. Component 3 (case investigation):Patients who have an isolate that is a critical CRO (rare or novel resistance mechanism or resistance to treatment) or identified as being part of possible nosocomial transmission will be included. Inpatient contacts identified through case investigation will be included. Component 4 (enhanced IPC) Individual patients will not be included in enhanced IPC. Wards selected for enhanced IPC will include ICUs and wards where critical CRO detection or nosocomial transmission is occurring.

Exclusion criteria

Exclusion criteria: Exclusion Criteria • Species not considered to be of concern for IPC activities • Age • Patient declines to participate in study activities

Design outcomes

Primary

MeasureTime frame
CRO, CP-CRO, and CR-CRO per 1,000 patient days. prevalence of CRO, CP-CRO, and CR-CRO colonization at admission. Changes in thefrequency of CRO, CP-CRO, and CR-CROTimepoint: six monthly

Secondary

MeasureTime frame
Change in technical capacity in bacteriology laboratories to detect and characterize CRO, CP-CRO, and CR-CROTimepoint: Baseline and endline

Countries

India

Contacts

Public ContactDrShaoli Basu

P. D. Hinduja Hospital and Medical Research Centre

dr_shaoli.basu@hindujahospital.com9819177726

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026