Health Condition 1: N186- End stage renal disease
Conditions
Interventions
Intervention1: ETHANOL LOCK
V/S
ANTIBIOTIC LOCK
A Prospective randomized control study for treatment of
CRBSI in patients undergoing MHD via Tunneled Catheters: ETHANOL LOCK
V/S
ANTIBIOTIC LOCK
A Pros
Sponsors
MPUH
Eligibility
Inclusion criteria
Inclusion criteria: Patients with Hemodialysis TCC that have been in place for at least 14 days with probable/ possible CRBSI as defined by KDOQI.
Exclusion criteria
Exclusion criteria: CRBSI within 14 days of insertion of TCC Patients with severe sepsis, septic shock, hypotension or who are considered otherwise unstable Patient with prosthetic valve Patient with signs of metastatic deep-seated infection such as osteomyelitis or septic pulmonary infarcts or endocarditis (as evidenced by vegetation on an echocardiogram), or septic thrombosis Patients with tunnel or catheter exit site infection or infusion port pocket abscess as manifested by purulence at the exit site or inflammation with erythema or induration of >1 cm in diameter.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| outcomes - 1. removal of permacath (TCC) due to persistent CRBSI 2. removal of permacath (TCC) due to any other cause 3. effectiveness of locking solution by disappearance of fever and blood culture becoming sterileTimepoint: above mentioned outcomes at day 7 - outcome 1,2,3 at day 30 - outcome 1,2 at day 50 - outcome 1,2 | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the efficacy of Ethanol lock V/S antibiotic lock in clearance of the infection as documented by negative blood cultures one week after completion of antibiotic therapy.Timepoint: 1 week | — |
Countries
India
Contacts
Public ContactDR AJEY JHA
MPUH
Outcome results
None listed