Health Condition 1: I480- Paroxysmal atrial fibrillation
Conditions
Interventions
Intervention1: Diltiazem: Diltiazem immediate release tablet 60mg stat dose
Control Intervention1: Diltiazem: Diltiazem intravenous infusion 5mg/Hr titrated upto 1.25mg/Hr every 15-60 mins to a maxi
Sponsors
AIIMS RISHIKESH
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age >18yrs 2.Patients presenting to ED of AIIMS Rishikesh with Atrial Fibrillation (AF)with rapid ventricular rate (Ventricular rate >110/min) and having received initial diltiazem iv bolus (weight based).
Exclusion criteria
Exclusion criteria: 1.Hemodynamically unstable patients a) Systolic BP b) Acutely altered mental status c) Signs of shock d) Ischemic chest discomfort e) Acute heart failure 2.Any patient requiring electrical cardioversion. 3.Patients diagnosed with acute myocardial infarction. 4.Patients already received another antiarrhythmic agent within 24 hours before inclusion in study. 5.Patients in whom oral drug cannot be administered. 6.Hepatic dysfunction a) Decompensated chronic liver failure b) Severe acute hepatitis 7.Patients diagnosed with pre-excitation syndromes. 8.Patients not consenting to be part of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Achievement of rate control i.e ventricular rate 110/min at 4 hours after enrolment in the study.Timepoint: 4 hour | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Need for additional intravenous (IV) boluses of diltiazem. 2. Need for switching from oral to iv infusion. 3. Need for another antiarrhythmic agent for rate control. 4. Need for vasopressor support. 5. Need for DC Cardioversion 6. Length of stay in the emergency department. 7. Length of in hospital stay. 8. Occurrence of any adverse effects. 9. Conversion to sinus rhythm. Timepoint: 4 hour | — |
Countries
India
Contacts
Public ContactJEWEL RANI JOSE
AIIMS RISHIKESH
Outcome results
None listed