Health Condition 1: R64- Cachexia
Conditions
Interventions
Intervention1: Ubidecarenone (Coenzyme Q): Dose: 100 mg
Frequency: Once a day
Route of administration: Oral
Duration of Intervention: 3 months
Control Intervention1: PLACEBO: Dose: 100 mg
Frequency:
Sponsors
ADITYA VIKRAM SINGH
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of either gender with age equal to or more than 18 years 2. Patients with diagnosis of any stage of cancer and receiving cisplatin based regimen 3. Patients having the ability to understand and sign a written informed consent document
Exclusion criteria
Exclusion criteria: 1. Patient receiving concomitant medication(s) known to cause or aggravate cancer chemotherapy induced cachexia 2. Patient receiving any other investigational agent 3. Psychological or sociological conditions, addictive disorders, or family problems that would preclude adherence with study drug or compliance with the protocol 4. Difficulty while swallowing oral medications due to prolonged emesis, mucositis, esophageal dysfunction, etc 5. History of allergy to Ubidecarenone 6. Patient with any infectious disease like TB, HIV-AIDS requiring pharmacotherapy 7. Patient with history of uncontrolled co-morbid conditions like diabetes mellitus, hypertension, chronic kidney disease, autoimmune diseases like amyloidosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in CASCO scale (Cachexia Score) rating and Body composition analysis of cancer chemotherapy induced cachexia patients after 3 months of interventionTimepoint: 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of physical and biochemical parameters with severity of cancer chemotherapy induced cachexiaTimepoint: 3 months;Difference in Body Composition Analysis (BCA) of cancer chemotherapy induced cachexia patientsTimepoint: 3 months;Difference in Quality of Life score (QoL) of cancer chemotherapy induced cachexia patients using CASCO questionnaire (Cachexia Score questionnaire)Timepoint: 3 months;Levels of leptin in cancer chemotherapy induced cachexia patientsTimepoint: 3 months | — |
Countries
India
Contacts
Public ContactADITYA VIKRAM SINGH
JAWAHARLAL NEHRU MEDICAL COLLEGE AND HOSPITAL ALIGARH MUSLIM UNIVERSITY
Outcome results
None listed