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The effect of a sugary drink before surgery in decreasing the blood levels of stress hormones.

Carbohydrate loading 2 hours prior to Surgery â?? Effects on Stress response â?? a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/11/047313
Enrollment
42
Registered
2022-11-15
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Oral Glucose Solution: Oral Carbohydrate drink â?? 200ml containing 25gm carbohydrate (Glucose) Control Intervention1: 500 ml of 5% Dextrose: The comparator arm will receive an iv of 50

Sponsors

Christian Medical College and Hospital, Vellore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age between 18 to 55 2.All ASA 1 and 2 patients undergoing minor surgeries 3.BMI between 18 to 30 4.Surgical Procedures lasting between 90 minutes and 300 minutes.

Exclusion criteria

Exclusion criteria: 1.Patient refusal 2.ASA More than 3 patients 3.BMI less than 18 and BMI more than 30 4.Emergency surgeries 5.Hyperthyroid Patients 6.Patients on Beta Blockers 7.Diabetic patients with HBA1C more than 7 and on treatment for Diabetes with insulin 8.Surgical Procedures lasting less than 90 minutes and more than 300 minutes. 9.Surgeries involving bowel preparation. 10.Patients who are unable to take oral diet. 11.Patients with gastric motility disorders. 12.Pregnant and Lactating mothers

Design outcomes

Primary

MeasureTime frame
Change in insulin resistance levels through various Insulin resistance indices like HOMO-IR, Matsuda Index, Insulinogenic Index and Disposition Index as compared to baseline values.Timepoint: Baseline, 30 minute intervals over 2 hours from the time of carbohydrate loading

Secondary

MeasureTime frame
i.Changes in preoperative Insulin and Glucose levels. ii.To determine a relationship between body composition and insulin resistance levelsTimepoint: i.Baseline and 30 minutes intervals over 2 hour period from the time of carbohydrate loading. ii.Baseline

Countries

India

Contacts

Public ContactDr Tony Thomson Chandy

CHRISTIAN MEDICAL COLLEGE AND HOSPITAL-VELLORE.

tonythomson@cmcvellore.ac.in9500242412

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026